How to configure Notepad++ to run a python script

Supposing that Notepad++ & Python (v2.7 in my case) are installed on your computer:

• Run CMD to open a command prompt
• Run the following command to set Python location in your system's PATH variable: 

set PATH=%PATH%;C:\Python27

Note: Amend python installation path based on your setup.

Use the following command to check that python path was successfully added to the PATH variable:

echo %PATH% 

You should see the location of the python directory at the end of the output.

• Start Notepad++, select Run menu, and then select Run... (F5)
• Insert the following in the pop up text box that appears: 

python.exe -i "$(FULL_CURRENT_PATH)"

• Click Save...
• Configure ALT+SHIFT+P (or any of your choice) as the command shortcut.  Give it a distinctive name (e.g. Execute Python), and press OK.

With this setup whenever you want to run the python program you're working on, press ALT+SHIFT+P or chose "Execute Python" from the Run Menu list. Note that because of the -i flag the Python console window stays open after the program execution for debugging purposes. If you don't want that just remove the -i flag.